Billy Twelvetrees marked an impressive international debut with one of England's four tries as Stuart Lancaster's men cut down Scotland to retain the Calcutta Cup in style.
Chris Ashton, Geoff Parling and Danny Care joined Twelvetrees on the score-sheet and the imperious Owen Farrell kicked 18 points as England recorded their biggest win over Scotland in six years.
Scotland did take a surprise early lead with a debut try from New Zealand-born wing Sean Maitland and they mounted a brief late rally with Stuart Hogg's breakaway try.
But the game had long been up by then and Scotland's 30-year wait for a win over England at Twickenham goes on.
England were back at their headquarters for the first time since the autumn triumph over world champions New Zealand, in which Manu Tuilagi had been the destroyer-in-chief.
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